专利检索 ap:("The Scripps Research Institute") AND inv:"Elvira Khialeeva" 第 1 页

1.

发明授权
Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof 有权

公开(公告)号：US11174306B2

公开(公告)日：2021-11-16

申请号：US16343353

申请日：2017-10-19

申请人： The Scripps Research Institute

发明人： Travis S. Young , Leonard Presta , David Rodgers , Eric Hampton , Timothy Wright , Peter G. Schultz , Eduardo Laborda , Elvira Khialeeva , Sophie Viaud

IPC分类号： C07K16/18 , A61P35/00 , C07K14/725 , C07K14/705 , C07K16/28 , A61K39/00

摘要： The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.