专利检索 ap:("The U.S.A., as represented by the Secretary, Department of Health AND Human Services") AND inv:"Jeffrey Baron" 第 1 页

1.

发明公开
MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND TO MATRILIN 3 AND THEIR USE 审中-公开

公开(公告)号：US20230331832A1

公开(公告)日：2023-10-19

申请号：US18317869

申请日：2023-05-15

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Jeffrey Baron , Crystal Sao Fong Cheung , Julian Chun Kin Lui , Dimiter Dimitrov , Zhongyu Zhu

IPC分类号： C07K16/18 , A61K47/68

CPC分类号： C07K16/18 , A61K47/6811 , A61K47/6843 , C07K14/78

摘要： Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.