公开(公告)号：US20210324090A1

公开(公告)日：2021-10-21

申请号：US17355703

申请日：2021-06-23

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Javed Khan ,  Sivasubramanian Baskar ,  Rimas J. Orentas ,  Dimiter S. Dimitrov ,  Zhongyu Zhu ,  Tai Chi Cheuk

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00 ,  A61K39/395

摘要： Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4 (FGFR4) are described. Chimeric antigen receptors, antibody-drug conjugates, immunoconjugates, bispecific antibodies and immunoliposomes comprising the disclosed FGFR4-specific antibodies are also described. The antibody compositions can be used to diagnose or treat a FGFR4-positive cancer, such as rhabdomyosarcoma, lung cancer, liver cancer, breast cancer, pancreatic cancer or prostate cancer.

公开(公告)号：US11078286B2

公开(公告)日：2021-08-03

申请号：US15761398

申请日：2016-09-19

申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Javed Khan ,  Sivasubramanian Baskar ,  Rimas J. Orentas ,  Dimiter S. Dimitrov ,  Zhongyu Zhu ,  Tai Chi Cheuk

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00 ,  A61K39/395

摘要： Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4 (FGFR4) are described. Chimeric antigen receptors, antibody-drug conjugates, immunoconjugates, bispecific antibodies and immunoliposomes comprising the disclosed FGFR4-specific antibodies are also described. The antibody compositions can be used to diagnose or treat a FGFR4-positive cancer, such as rhabdomyosarcoma, lung cancer, liver cancer, breast cancer, pancreatic cancer or prostate cancer.