专利检索 ap:("The United States Government As Represented By The Department Of Veterans Affairs" OR "THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA" OR "OKLAHOMA MEDICAL RESEARCH FOUNDATION") AND inv:"CARLA R. SCANZELLO" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS USING A CD14 INHIBITOR 审中-公开

公开(公告)号：US20240239913A1

公开(公告)日：2024-07-18

申请号：US18411242

申请日：2024-01-12

申请人： The United States Government As Represented By The Department Of Veterans Affairs , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , OKLAHOMA MEDICAL RESEARCH FOUNDATION

发明人： CARLA R. SCANZELLO , TIMOTHY GRIFFIN

IPC分类号： C07K16/28 , A61P19/02 , C07K14/745 , C12N9/12 , A61K38/00 , A61K39/00

CPC分类号： C07K16/2896 , A61P19/02 , C07K14/7455 , C12N9/12 , A61K38/00 , A61K2039/505 , C12Y207/12002

摘要： Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject.