专利检索 ap:("The United States of America, as Represented by the Secretary,Department of Health AND Human Service") AND inv:"Dominic Esposito" 第 1 页

1.

发明申请
DETECTION OF BCL-2 FAMILY HETERODIMER COMPLEXES AND USE THEREOF 有权

公开(公告)号：US20220074944A1

公开(公告)日：2022-03-10

申请号：US17422972

申请日：2020-01-29

申请人： The United States of America, as Represented by the Secretary,Department of Health and Human Service

发明人： Apurva Kumar Srivastava , Dominic Esposito , Jeevan Prasaad Govindharajulu , Ralph Ewin Parchment , James Halpern Doroshow

IPC分类号： G01N33/574 , G01N33/543

摘要： Immunoassays to detect the presence of Bcl-2 family heterodimeric complexes are described. The immunoassays are designed to detect one or more of BIM-Bcl-2, BIM-Bcl-xL, BIM-Mcl-1 and BAX-BAK heterodimers. The assays can be used, for example, to select a BH3 mimetic, or other drug targeting the apoptosis pathway, that is effective for treating a specific cancer, or to select a subject who is likely to respond to a particular BH3 mimetic.