专利检索 ap:("The United States of America, as represented by the Secretary, Dep. of Health AND Human Services") AND inv:"Qiong J. WANG" 第 1 页

1.

发明申请
ANTI-MUTATED KRAS T CELL RECEPTORS 审中-公开

公开(公告)号：US20170304421A1

公开(公告)日：2017-10-26

申请号：US15528813

申请日：2015-11-24

申请人： The United States of America, as represented by the Secretary, Dep. of Health and Human Services

发明人： Qiong J. WANG , Zhiya YU , James C. YANG

IPC分类号： A61K39/00 , G01N33/574 , C07K14/725

CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5152 , C07K14/7051 , C07K14/82 , C12Y306/00 , G01N33/5748 , G01N2333/914

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.