专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Serv") AND inv:"Sunmin Lee" 第 1 页

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发明申请
NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER 审中-公开

公开(公告)号：US20190047932A1

公开(公告)日：2019-02-14

申请号：US16107532

申请日：2018-08-21

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv

发明人： Jane B. Neckers , Yeong Sang Kim , Sunmin Lee , Vineet Kumar , Sanjay V. Malhotra

IPC分类号： C07C49/796 , C07C49/84 , C07C49/813 , C07C49/80 , A61K45/06 , A61K31/12 , C07C255/56 , C07C205/45 , A61K31/275

摘要： Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.