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公开(公告)号：US20210179700A1
公开(公告)日：2021-06-17
申请号：US17177644
申请日：2021-02-17
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
摘要： Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
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公开(公告)号：US20190248880A1
公开(公告)日：2019-08-15
申请号：US16391101
申请日：2019-04-22
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
CPC分类号： C07K16/18 , A61K47/6811 , A61K47/6843 , A61K2039/505 , C07K14/78
摘要： Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.
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