公开(公告)号：US10287297B2

公开(公告)日：2019-05-14

申请号：US15564353

申请日：2016-04-13

申请人： The United States of America, as represented by the Secretary, Department of Heatlh and Human Services ,  Fundació Institut Català d'Investigació Química (ICIQ) ,  Universitat Rovira i Virgili

发明人： John A. Beutler ,  Antonio M. Echavarren ,  Laura Lopez ,  Fernando Bravo ,  Lorena Riesgo ,  Tanya Tannaquil Ransom

IPC分类号： C07D493/08 ,  A61P35/02 ,  C07D487/08 ,  C07D495/08 ,  A61P3/10

摘要： Disclosed is a compound of formula (I) in which R1-R5 and X1 are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer and a method of treating diabetes.

公开(公告)号：US11098054B2

公开(公告)日：2021-08-24

申请号：US16628768

申请日：2018-07-05

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services ,  Fundacio Institut Catala D'Investigacio Quimica ,  University of Delaware ,  University of Leeds ,  Universitat Rovira I Virgili

发明人： John A. Beutler ,  Antonio Echavarren ,  William Chain ,  David Beech ,  Zhenhua Wu ,  Jean-Simon Suppo ,  Fernando Bravo ,  Hussein Rubaiy

IPC分类号： C07D493/08 ,  A61P35/00 ,  C07D495/08 ,  C07D471/08

摘要： Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.