公开(公告)号：US20160311910A1

公开(公告)日：2016-10-27

申请号：US15101583

申请日：2014-10-30

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Haiying Qin ,  Terry J. Fry

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K14/715 ,  C07K16/30 ,  C07K14/705

摘要： The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for TSLPR, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of a proliferative disorder, e.g., cancer, in a mammal and methods of treating or preventing a proliferative disorder, e.g., cancer, in a mammal are also disclosed.

摘要翻译： 本发明提供了包含对TSLPR特异性的抗原结合结构域，跨膜结构域和细胞内T细胞信号结构域的嵌合抗原受体（CAR）。 公开了核酸，重组表达载体，宿主细胞，细胞群，抗体或其抗原结合部分以及与CAR相关的药物组合物。 还公开了在哺乳动物中检测哺乳动物中增殖性疾病例如癌症的存在的方法以及治疗或预防哺乳动物中增殖性疾病例如癌症的方法。