公开(公告)号：US20140219978A1

公开(公告)日：2014-08-07

申请号：US14106031

申请日：2013-12-13

申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services

发明人： Nicholas P. Restifo ,  Lydie Cassard ,  Zhiya Yu ,  Steven A. Rosenberg

IPC分类号： C07K14/705 ,  G01N33/574 ,  C12N15/86 ,  C07K16/30 ,  C12N15/85

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/7051 ,  C07K16/30 ,  C12N15/85 ,  C12N15/86 ,  G01N33/57492

摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.

摘要翻译： 本发明提供了包含对癌抗原gp100具有抗原特异性的鼠T细胞受体（TCR）的人细胞，特别是人T细胞。 具有对gp100（SEQ ID NO：1）的氨基酸154-162具有抗原特异性的分离或纯化的TCR，以及相关多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体或抗原结合 其片段，缀合物和药物组合物。 本发明还提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法，所述方法包括使用本文所述的本发明材料。