专利检索 ap:("The United States of America, as represented by the Secretary, Dept.of Health AND Human Services") AND inv:"Bharatkumar H. Joshi" 第 1 页

1.

发明公开
IL-13RA2 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE 审中-公开

公开(公告)号：US20240189351A1

公开(公告)日：2024-06-13

申请号：US18285218

申请日：2022-04-01

申请人： The United States of America, as represented by the Secretary, Dept.of Health and Human Services

发明人： Raj K. Puri , Bharatkumar H. Joshi

IPC分类号： A61K35/17 , A61K39/00 , A61K45/06 , A61P35/00 , C07K16/28 , C12N5/0783 , C12N15/86

CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464419 , A61K45/06 , A61P35/00 , C07K16/2866 , C12N5/0636 , C12N15/86 , A61K2239/13 , A61K2239/17 , A61K2239/21 , A61K2239/22 , C12N2740/15043

摘要： Immunotherapies, particularly chimeric antigen receptors targeting IL-13Rα2 and their use for treating cancer are provided. A single chain fragment variable (scFv) that specifically binds IL-13Rα2, chimeric antigen receptors (CARs) including the IL-13Rα2 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs are provided. Also provided are methods of treating a subject with cancer, including administering to the subject an immune cell expressing an IL-13Rα2 scFv-CAR alone or in combination with other cancer therapies.