公开(公告)号：US20180318435A1

公开(公告)日：2018-11-08

申请号：US15773687

申请日：2016-11-10

申请人： The United States of America,as represented by the Secretary, Department of Health and Human Service ,  Sanford Research

发明人： Ira H. Pastan ,  Tapan Bera ,  Satoshi Nagata ,  Tomoko Ise ,  Yasuhiro Abe

IPC分类号： A61K47/64 ,  A61K39/00 ,  C07K16/28

CPC分类号： A61K47/6415 ,  A61K39/00 ,  A61K47/6425 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2319/03

摘要： Polypeptides and proteins that specifically bind to and immunologically recognize B-Cell Maturation Antigen (BCMA) are disclosed. Chimeric antigen receptors (CARs), anti-BCMA binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer and methods of treating or preventing cancer are also disclosed.

公开(公告)号：US20200247901A1

公开(公告)日：2020-08-06

申请号：US16613971

申请日：2018-05-17

申请人： The United States of America, as represented by the Secretary,Department of Health and Human Service

发明人： Ira H. Pastan ,  Masanori Onda ,  Tapan Bera ,  Mitchell Ho

IPC分类号： C07K16/30 ,  A61K47/68 ,  G01N33/574 ,  A61P35/00

摘要： Polypeptides and proteins that specifically bind to and immunologically recognize human mesothelin582-598 (IP-NGYLVLDLSMQEALS) (SEQ ID NO: 1) are disclosed. Anti-mesothelin binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are disclosed. Methods of reducing mesothelin shed from cell membranes, methods of reducing the activity of TNFα converting enzyme, methods of detecting the presence of cancer, and methods of treating or preventing cancer are also disclosed.