专利检索 ap:("The United States of America, as represented by the Secretary of Agriculture" OR "LOS ALAMOS NATIONAL SECURITY, LLC") AND inv:"Devendra K. Rai" 第 1 页

1.

发明授权
Mosaic vaccines for serotype a foot-and-mouth disease virus 有权

公开(公告)号：US10172933B2

公开(公告)日：2019-01-08

申请号：US15785875

申请日：2017-10-17

申请人： The United States of America, as represented by the Secretary of Agriculture , LOS ALAMOS NATIONAL SECURITY, LLC

发明人： Aida E. Rieder , William M. Fischer , Devendra K. Rai

IPC分类号： A61K39/135 , C12N7/00 , A61K39/12 , A61K39/00

摘要： Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. The mosaic polypeptides have greater T-cell epitope coverage than naturally occurring FMDV polypeptides, and include common FMDV epitopes, but exclude rare FMDV epitopes. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype A FMDV strains.