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公开(公告)号：US20200223937A1
公开(公告)日：2020-07-16
申请号：US16648369
申请日：2018-09-18
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Ira H. Pastan , Junxia Wei , Masanori Onda , Tapan Bera , Mitchell Ho
摘要： Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
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公开(公告)号：US11795235B2
公开(公告)日：2023-10-24
申请号：US16648369
申请日：2018-09-18
发明人： Ira H. Pastan , Junxia Wei , Masanori Onda , Tapan Bera , Mitchell Ho
CPC分类号： C07K16/30 , C07K14/21 , C07K16/2803 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/569 , C07K2317/624 , C07K2317/73 , C07K2317/94 , C07K2319/33 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
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公开(公告)号：US20240228657A9
公开(公告)日：2024-07-11
申请号：US18471137
申请日：2023-09-20
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Ira H. Pastan , Junxia Wei , Masanori Onda , Tapan Bera , Mitchell Ho
CPC分类号： C07K16/30 , C07K14/21 , C07K16/2803 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/569 , C07K2317/624 , C07K2317/73 , C07K2317/94 , C07K2319/33 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
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公开(公告)号：US20240132619A1
公开(公告)日：2024-04-25
申请号：US18471137
申请日：2023-09-19
申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
发明人： Ira H. Pastan , Junxia Wei , Masanori Onda , Tapan Bera , Mitchell Ho
CPC分类号： C07K16/30 , C07K14/21 , C07K16/2803 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/569 , C07K2317/624 , C07K2317/73 , C07K2317/94 , C07K2319/33 , C07K2319/50 , C07K2319/55 , C07K2319/70
摘要： Disclosed is a molecule comprising: (a) a first domain, which comprises a targeting moiety; (b) a second domain, which comprises an albumin binding domain (ABD), (c) a third domain, which comprises a furin cleavage sequence (“FCS”), which FCS is cleavable by furin; and (d) a fourth domain, which comprises an optionally substituted Domain III from Pseudomonas exotoxin A (“PE”). Related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of producing the molecule, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
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