专利检索 ap:("The United States of America,as represented by the Secretary,Department of Health AND Human Services" OR "The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.") AND inv:"Zhiji Luo" 第 1 页

1.

发明申请
QUINOLINE COMPOUNDS AND THEIR PREPARATION AND USE AS ANTIMALARIAL AGENTS 有权

公开(公告)号：US20210188843A1

公开(公告)日：2021-06-24

申请号：US17054614

申请日：2019-05-13

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： Wenwei Huang , Hao Li , Wei Zheng , Wei Sun , Xiuli Huang , Xiao Lu , Philip E. Sanderson , Xin Xu , Pranav Shah , Kim C. Williamson , Zhiji Luo , Gregory J. Tawa

IPC分类号： C07D471/04 , A61P33/06 , C07D519/00

摘要： Disclosed are compounds of formula (I) wherein R1, R2, R3, A, and B are as defined herein, and a method of preparing such compounds. Also disclosed are pharmaceutical compositions containing the compound of formula (I) and a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria by killing or arresting the growth of Plasmodium organisms in a mammal, wherein the Plasmodium organisms are in a liver stage, an asexual stage, or gametocytes, comprising administering to an animal an effective amount of a compound of formula (I).