公开(公告)号：US09700578B2

公开(公告)日：2017-07-11

申请号：US14589324

申请日：2015-01-05

申请人： The United States of America as represented by the Secretary of the Department of Health and Human Services ,  The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Acting through Louisiana State University Health Sciences Center ,  The UAB Research Foundation ,  Loma Linda University ,  Wake Forest University

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

IPC分类号： A61K33/00 ,  A61K45/06

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

公开(公告)号：US20150125553A1

公开(公告)日：2015-05-07

申请号：US14589324

申请日：2015-01-05

申请人： The Government of the United States of America as represented by the Secretary of the Department of ,  The Board of Supervisors of Louisiana State Univer and Agricultural and Mechanical College, Acting t ,  The UAB Research Foundation ,  Loma Linda University ,  Wake Forest University

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

IPC分类号： A61K33/00

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血 - 再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US20170281673A1

公开(公告)日：2017-10-05

申请号：US15630017

申请日：2017-06-22

申请人： The Government of the U.S.A. as represented by the Sec. of the Dept. of Health and Human Services ,  Loma Linda University ,  Wake Forest University

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Richard O. Cannon, III

IPC分类号： A61K33/00 ,  A61K45/06

CPC分类号： A61K33/00 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.