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1.发明授权公开(公告)号：US09198914B2
公开(公告)日：2015-12-01
申请号：US14074395
申请日：2013-11-07
IPC分类号： A61K31/535 , A61K31/5377 , A61K31/00 , A61K31/18 , A61K31/415 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/18 , A61K31/415 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K45/06 , A61K2300/00
摘要： The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
摘要翻译： 本发明涉及涉及RAD51的抑制剂和增强剂的方法和组合物，RAD51是参与同源重组的蛋白质。 在一些实施方案中，本发明涉及刺激同源重组的方法，其具有许多重要的研究和临床应用。 在某些其他实施方案中，存在使用增强RAD51活性的化合物来保护细胞的方法。 也可以使用这种增强剂来预防或减少由DNA损伤剂引起的对细胞的损伤。 在其他实施方案中，存在使细胞对DNA损伤剂的作用敏感的方法，其可以具有癌症患者的特殊应用。 在本发明的一些实施方案中，RAD51增强子或抑制剂是直接影响RAD51活性的小分子，例如其促进细丝形成的能力。
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2.发明申请公开(公告)号：US20140142103A1
公开(公告)日：2014-05-22
申请号：US14074395
申请日：2013-11-07
IPC分类号： A61K31/5377 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/18 , A61K31/415 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K45/06 , A61K2300/00
摘要： The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
摘要翻译： 本发明涉及涉及RAD51的抑制剂和增强剂的方法和组合物，RAD51是参与同源重组的蛋白质。 在一些实施方案中，本发明涉及刺激同源重组的方法，其具有许多重要的研究和临床应用。 在某些其他实施方案中，存在使用增强RAD51活性的化合物来保护细胞的方法。 也可以使用这种增强剂来预防或减少由DNA损伤剂引起的对细胞的损伤。 在其他实施方案中，存在使细胞对DNA损伤剂的作用敏感的方法，其可以具有癌症患者的特殊应用。 在本发明的一些实施方案中，RAD51增强子或抑制剂是直接影响RAD51活性的小分子，例如其促进细丝形成的能力。
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公开(公告)号：US10912761B2
公开(公告)日：2021-02-09
申请号：US14648115
申请日：2013-11-27
IPC分类号： A61K31/496 , A61K31/5377 , C07D207/456 , A61K31/402
摘要： The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
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公开(公告)号：US20150306069A1
公开(公告)日：2015-10-29
申请号：US14648115
申请日：2013-11-27
IPC分类号： A61K31/402 , A61K31/496 , A61K31/5377
CPC分类号： A61K31/402 , A61K31/496 , A61K31/5377 , C07D207/456
摘要： The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
摘要翻译： 本发明涉及涉及抑制剂和参与同源重组的蛋白质RAD51的方法和组合物。 在一些实施方案中，存在使细胞对DNA损伤剂的作用敏感的方法，其可以具有癌症患者的特殊应用。 在本发明的一些实施方案中，RAD51抑制剂是直接影响RAD51活性的小分子，例如其促进丝状细胞形成的能力。
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5.发明申请METHODS AND COMPOSITIONS RELATING TO CANCER THERAPY WITH DNA DAMAGING AGENTS 审中-公开与DNA损伤剂相关的癌症治疗方法和组合物公开(公告)号：US20160369353A1
公开(公告)日：2016-12-22
申请号：US15078810
申请日：2016-03-23
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G16B40/00
摘要： Methods and compositions are provided for predicting efficacy of a DNA damaging agent in a cancer patient or treating a cancer patient with a DNA damaging agent after evaluating efficacy. In some embodiments, an algorithm is used to evaluate efficacy and treatment.
摘要翻译： 提供了方法和组合物，用于在评估功效后，预测DNA损伤剂在癌症患者中的功效或用DNA损伤剂治疗癌症患者。 在一些实施例中，使用算法来评估功效和治疗。
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