公开(公告)号：US20250154508A1

公开(公告)日：2025-05-15

申请号：US18841152

申请日：2023-02-24

Applicant: THE UNIVERSITY OF CHICAGO

Inventor： Bryan DICKINSON ,  Yang CAO ,  Mark BERNEY

IPC: C12N15/113

Abstract: The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA. Further described are circular nucleic acids comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA.

公开(公告)号：US20230090706A1

公开(公告)日：2023-03-23

申请号：US17905116

申请日：2021-02-26

Applicant: The University of Chicago

Inventor： Bryan DICKINSON ,  Yang CAO

IPC: C12N15/113 ,  C12N15/67

Abstract: The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA.