专利检索 ap:("The University of Chicago" OR "Loyola University of Chicago") AND inv:"David J. Hosfield" 第 1 页

1.

发明公开
ESTROGEN RECEPTOR ALPHA ANTAGONISTS AND USES THEREOF 审中-公开

公开(公告)号：US20240150294A1

公开(公告)日：2024-05-09

申请号：US18546525

申请日：2022-02-17

申请人： The University of Chicago , Loyola University of Chicago

发明人： Sean W. Fanning , Geoffrey L. Greene , David J. Hosfield

IPC分类号： C07D221/20 , A61K45/06 , A61P35/00 , C07D401/12

CPC分类号： C07D221/20 , A61K45/06 , A61P35/00 , C07D401/12

摘要： Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, R5, X1, X2, and n are described herein. Also provided is a method of treating an estrogen-mediated disease requiring inhibition of estrogen receptor alpha (ER-alpha), such as cancer, in a subject or inhibiting ER-alpha in a cell with the compound of formula (I) or a pharmaceutically acceptable salt thereof.