公开(公告)号：US20020045664A1

公开(公告)日：2002-04-18

申请号：US09981617

申请日：2001-10-15

申请人： The University of Georgia Research Foundation, Inc

发明人： Peter C. Ruenitz

IPC分类号： A61K031/192

CPC分类号： C07D257/04 ,  A61K31/192 ,  C07C43/23 ,  C07C59/68 ,  C07F9/386

摘要： A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I) 1 wherein R1 is nullO(CH2)mR3 or null(CH2)nR3; wherein R3 is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R2 is either H or nullOH. Each of R1 and R2 can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R1 is nullO(CH2)mR3 or null(CH2)nR3; R3 is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R2is H or nullOH; and wherein each of R1 and R2 is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R2 is not para nullOH when m is 1 and R3 is nullCOOH.

摘要翻译： 使用式（I）的三芳烷（其中R 1为-O（CH 2）m R 3或 - （CH 2）n R 3）治疗对雌激素治疗有反应的外生殖道组织中的症状，疾病和状况的方法。 其中R3是阴离子取代基; m是1至4的整数; 且n为0至4的整数; 并且其中R2是H或-OH。 R1和R2中的每一个可以是其相应的苯基乙基链的间位或对位。 具有式（I）的化合物，其中R 1为-O（CH 2）m R 3或 - （CH 2）n R 3; R3是阴离子取代基; m为1,2,3或4; n为0,1,2,3或4; R2是H或-OH; 并且其中R 1和R 2各自独立地为其各自的苯乙基的间位或对位，条件是当m为1时，R 2不为对位-OH，且R 3为-COOH。