专利检索 ap:("The University of Hong Kong") AND inv:"Hin Yuk LAI" 第 1 页

1.

发明公开
N-ACRYLOYLINDOLES AND METHODS OF USE 审中-公开

公开(公告)号：US20240103005A1

公开(公告)日：2024-03-28

申请号：US18307905

申请日：2023-04-27

申请人： The University of Hong Kong

发明人： Yik Sham Clive CHUNG , Hin Yuk LAI , Tin Yan KOO , Yui Yan Hillary YIP

IPC分类号： G01N33/68 , C07D209/08 , C07D403/12

CPC分类号： G01N33/6815 , C07D209/08 , C07D403/12 , G01N2458/00

摘要： The subject invention pertains to a new class of compounds, N-acryloylindole (NAIs), and methods of using NAIs as cysteine-reactive probes for proteome-wide cysteine profiling and imaging of thiol oxidative modifications. NAIs are capable of imaging oxidized thiols in cells facing oxidative stress by confocal fluorescence microscopy. NAIs can capture populations of cysteines, particularly those involved in gene expression and regulation.