专利检索 ap:("The University of Manchester") AND inv:"Edward Raymond Ballister" 第 1 页

1.

发明公开
MODULATING OPSIN SIGNALING LIFETIME FOR OPTOGENETIC APPLICATIONS 审中-公开

公开(公告)号：US20230165938A1

公开(公告)日：2023-06-01

申请号：US17754721

申请日：2020-10-13

申请人： The University of Manchester

发明人： Robert Lucas , Jessica Rodgers , Edward Raymond Ballister

IPC分类号： A61K38/17 , A61K48/00 , A61P27/02

CPC分类号： A61K38/1774 , A61K38/177 , A61K48/0008 , A61K48/0075 , A61P27/02

摘要： The present disclosure provides compositions comprising an opsin polypeptide and an arrestin polypeptide and their use thereof. Exemplary embodiments provide a composition including an opsin polypeptide, or an opsin polypeptide and an arrestin polypeptide, wherein at least one of the opsin or arrestin polypeptide comprises at least one mutation that increases a temporal resolution of the opsin polypeptide’s response to light. The opsin polypeptide and the arrestin polypeptide can be operably linked or separate. Additionally, use of said compositions for restoring retinal photosensitivity or treating a retinal degenerative condition is also provided.