公开(公告)号：US10383956B2

公开(公告)日：2019-08-20

申请号：US15324147

申请日：2015-07-10

Applicant: The University of Tokyo

Inventor： Yasuteru Urano ,  Yasuyuki Seto ,  Haruna Onoyama ,  Yugo Kuriki ,  Mako Kamiya

IPC: A61K49/00 ,  C12M1/00 ,  A61B1/04

Abstract: [Problem] To provide a novel fluorescent probe for dipeptidyl peptidase IV, and a detection method and a detection kit using the fluorescent probe.[Solution] A fluorescent probe for detecting dipeptidyl peptidase IV (DPP-IV), said probe comprising a compound represented by formula (I) or a salt thereof. In formula (I): A and B are either the same or different and independently represent an amino acid residue, provided that A is bonded via an amide bond to NH in an adjacent formula and B is bonded via an amide bond to A; R1 represents hydrogen atom(s) or 1 to 4 substituents bonded to the benzene ring, said substituents being either the same or different; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; and X represents a C1-C3 alkylene group.