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1.发明申请Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same 有权过氧化物酶体增殖物激活受体（PPAR）激动剂的类似物及其使用方法公开(公告)号：US20160016920A1
公开(公告)日：2016-01-21
申请号：US14773022
申请日：2014-03-14
Applicant: THE UNIVERSITY OF TOLEDO
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul Erhardt , Brian Kress
IPC: C07D277/22
CPC classification number: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , A61K2300/00
Abstract: Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
Abstract translation: PPAR5的类似物和分别为PPAR5激动剂和20-OH-PGE2拮抗剂的20-OH-PGE2的类似物及其用于诱导成骨或软骨形成的方法。
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2.发明授权公开(公告)号：US09695137B2
公开(公告)日：2017-07-04
申请号：US14773022
申请日：2014-03-14
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul Erhardt , Brian Kress
IPC: C07D277/22 , A61K31/426 , A61K31/5575 , A61K45/06
CPC classification number: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , A61K2300/00
Abstract: Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed.
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公开(公告)号：US10351541B2
公开(公告)日：2019-07-16
申请号：US15593750
申请日：2017-05-12
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul Erhardt , Brian Kress
IPC: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20170283385A1
公开(公告)日：2017-10-05
申请号：US15593750
申请日：2017-05-12
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul Erhardt , Brian Kress
IPC: C07D277/24
CPC classification number: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , A61K2300/00
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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公开(公告)号：US11897852B2
公开(公告)日：2024-02-13
申请号：US17172543
申请日：2021-02-10
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul W. Erhardt , Brian Kress
IPC: A61K31/426 , A61P19/02 , C07D277/24 , A61K31/5575 , A61K45/06 , C07D277/28 , C07D277/22
CPC classification number: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/22 , C07D277/28 , A61K31/5575 , A61K2300/00 , A61K31/426 , A61K2300/00
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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公开(公告)号：US20210163431A1
公开(公告)日：2021-06-03
申请号：US17172543
申请日：2021-02-10
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul W. Erhardt , Brian Kress
IPC: C07D277/24 , A61K31/426 , A61K31/5575 , A61K45/06 , C07D277/28 , C07D277/22
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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公开(公告)号：US10941125B2
公开(公告)日：2021-03-09
申请号：US16504815
申请日：2019-07-08
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul W. Erhardt , Brian Kress
IPC: C07D277/26 , C07D277/28 , A61K31/426 , C07D277/24 , A61K31/5575 , A61K45/06 , C07D277/22
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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8.发明申请公开(公告)号：US20190330166A1
公开(公告)日：2019-10-31
申请号：US16504815
申请日：2019-07-08
Applicant: The University of Toledo
Inventor： Bruce E. Heck , Dong Hyun Kim , Paul W. Erhardt , Brian Kress
IPC: C07D277/24 , C07D277/22 , A61K31/426 , A61K31/5575 , A61K45/06
Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
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