公开(公告)号：US20070043059A1

公开(公告)日：2007-02-22

申请号：US11504050

申请日：2006-08-15

申请人： Theodorus Koopman ,  Hendrik Koster ,  Peter Van Amsterdam ,  Roelof Feenstra ,  Marinus Verhage ,  Andrew McCreary ,  Mayke Hesselink ,  Gustaaf Van Scharrenburg

发明人： Theodorus Koopman ,  Hendrik Koster ,  Peter Van Amsterdam ,  Roelof Feenstra ,  Marinus Verhage ,  Andrew McCreary ,  Mayke Hesselink ,  Gustaaf Van Scharrenburg

IPC分类号： A61K31/496 ,  A61K31/4545 ,  A61K31/454 ,  C07D413/14 ,  C07D413/04

CPC分类号： C07D263/58 ,  C07D413/04

摘要： The present disclosure relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The disclosure also relates to the use of the compounds for the manufacture of a medicament giving a beneficial effect. The disclosure also relates to the use of the compounds for the manufacture of a medicament for treating or preventing a disease or condition. The disclosure further relates to the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

摘要翻译： 本公开内容涉及某些哌嗪和哌啶衍生物的N-氧化物以及这些化合物的制备方法。 本公开还涉及该化合物在制备产生有益效果的药物中的用途。 本公开还涉及化合物在制备用于治疗或预防疾病或病症的药物中的用途。 本发明还涉及中枢神经系统疾病的治疗，特别是焦虑症的治疗，包括广泛性焦虑障碍和恐慌症，强迫症，侵略，成瘾（包括渴望），抑郁症，孤独症，眩晕，精神分裂症等精神病 疾病，帕金森病和认知和记忆障碍。 化合物具有通式（1），其中符号具有说明书中给出的含义。