公开(公告)号：US20150175699A1

公开(公告)日：2015-06-25

申请号：US14408128

申请日：2013-03-12

Applicant: Therapix Biosciences Ltd.

Inventor： Ronald Ellis ,  Michael Tal ,  Sarit Samira ,  Nurit Rachamim ,  Timothy David Jones ,  Francis Joseph Carr ,  Shahar Dotan

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624

Abstract: Humanized monoclonal antibodies (mAbs) or fragments thereof, to human Cluster of Differentiation 3 (CD3), which confer improved immune stimulation and stability, are disclosed. Pharmaceutical compositions comprising said mAbs and methods of treatment and optionally also prevention of diseases and disorders, such as autoimmune disorders, infectious diseases, and transplant rejection, that are susceptible to amelioration by binding to CD3, are also disclosed.

Abstract translation: 公开了赋予改善的免疫刺激和稳定性的分化3群（CD3）的人源化单克隆抗体（mAb）或其片段。 还公开了包含所述mAb的药物组合物，以及通过与CD3结合而易于改善的治疗方法和任选地还可预防疾病和病症，例如自身免疫疾病，感染性疾病和移植排斥反应。

公开(公告)号：US20180244778A1

公开(公告)日：2018-08-30

申请号：US15979197

申请日：2018-05-14

Applicant: Therapix Biosciences Ltd.

Inventor： Ronald Ellis ,  Michael Tal ,  Sarit Samira ,  Nurit Rachamim ,  Timothy David Jones ,  Francis Joseph Carr ,  Shahar Dotan

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624

Abstract: Humanized monoclonal antibodies (mAbs) or fragments thereof, to human Cluster of Differentiation 3 (CD3), which confer improved immune stimulation and stability, are disclosed. Pharmaceutical compositions comprising said mAbs and methods of treatment and optionally also prevention of diseases and disorders, such as autoimmune disorders, infectious diseases, and transplant rejection, that are susceptible to amelioration by binding to CD3, are also disclosed.

公开(公告)号：US10000567B2

公开(公告)日：2018-06-19

申请号：US14408128

申请日：2013-03-12

Applicant: Therapix Biosciences Ltd.

Inventor： Ronald Ellis ,  Michael Tal ,  Sarit Samira ,  Nurit Rachamim ,  Timothy David Jones ,  Francis Joseph Carr ,  Shahar Dotan

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2809 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624

Abstract: Humanized monoclonal antibodies (mAbs) or fragments thereof, to human Cluster of Differentiation 3 (CD3), which confer improved immune stimulation and stability, are disclosed. Pharmaceutical compositions comprising said mAbs and methods of treatment and optionally also prevention of diseases and disorders, such as autoimmune disorders, infectious diseases, and transplant rejection, that are susceptible to amelioration by binding to CD3, are also disclosed.