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    COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES
    1.
    发明申请
    COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
    用于治疗呼吸道疾病的药物的组合

    公开(公告)号：US20140056823A1

    公开(公告)日：2014-02-27

    申请号：US14071035

    申请日：2013-11-04

    申请人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    发明人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    IPC分类号： A61K31/538 ,  A61K31/439

    CPC分类号： A61K31/538 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/124 ,  A61K31/40 ,  A61K31/439 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

    摘要翻译： 一种药物组合物，其包含：（a）式1的化合物，其中：n为1或2; R 1是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; R 2是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; 和R 3是氢，C 1-4 - 烷基，OH，卤素，O-C 1-4 - 烷基，O-C 1-4 - 亚烷基-COOH或O-C 1-4亚烷基-COO-C 1-4烷基， 或其对映异构体，对映体或其外消旋体的混合物，或其酸加成盐与其可药用酸或其溶剂合物或水合物; 和（b）另一种活性物质2，其中式1化合物与活性物质2的摩尔比为1:10至12:1。

    COMBINATION OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES
    2.
    发明申请
    COMBINATION OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
    用于治疗呼吸系统疾病的药物的组合

    公开(公告)号：US20110135582A1

    公开(公告)日：2011-06-09

    申请号：US13028434

    申请日：2011-02-16

    申请人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    发明人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    IPC分类号： A61K31/538 ,  A61K9/12 ,  A61P11/00

    CPC分类号： A61K31/538 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/124 ,  A61K31/40 ,  A61K31/439 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

    摘要翻译： 一种药物组合物，其包含：（a）式1的化合物，其中：n为1或2; R 1是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; R 2是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; 和R 3是氢，C 1-4 - 烷基，OH，卤素，O-C 1-4 - 烷基，O-C 1-4 - 亚烷基-COOH或O-C 1-4亚烷基-COO-C 1-4烷基， 或其对映异构体，对映体或其外消旋体的混合物，或其酸加成盐与其可药用酸或其溶剂合物或水合物; 和（b）另一种活性物质2，其中式1化合物与活性物质2的摩尔比为1:10至12:1。

    COMBINATION OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES
    3.
    发明申请
    COMBINATION OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
    用于治疗呼吸系统疾病的药物的组合

    公开(公告)号：US20120263655A1

    公开(公告)日：2012-10-18

    申请号：US13537589

    申请日：2012-06-29

    申请人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    发明人： Thierry BOUYSSOU ,  Michael P. PIEPER ,  Andreas SCHNAPP

    IPC分类号： A61K31/5386 ,  A61P11/00 ,  A61P11/06 ,  A61K9/12

    CPC分类号： A61K31/538 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/124 ,  A61K31/40 ,  A61K31/439 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition comprising: (a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

    摘要翻译： 一种药物组合物，其包含：（a）式1的化合物，其中：n为1或2; R 1是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; R 2是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; 和R 3是氢，C 1-4 - 烷基，OH，卤素，O-C 1-4 - 烷基，O-C 1-4 - 亚烷基-COOH或O-C 1-4亚烷基-COO-C 1-4烷基， 或其对映异构体，对映体或其外消旋体的混合物，或其酸加成盐与其可药用酸或其溶剂合物或水合物; 和（b）另一种活性物质2，其中式1化合物与活性物质2的摩尔比为1:10至12:1。

    COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES
    7.
    发明申请
    COMBINATIONS OF MEDICAMENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
    用于治疗呼吸道疾病的药物的组合

    公开(公告)号：US20140286879A1

    公开(公告)日：2014-09-25

    申请号：US14302780

    申请日：2014-06-12

    申请人： Thierry BOUYSSOU ,  Michael Paul PIEPER ,  Andreas SCHNAPP

    发明人： Thierry BOUYSSOU ,  Michael Paul PIEPER ,  Andreas SCHNAPP

    IPC分类号： A61K31/538 ,  A61K31/439

    CPC分类号： A61K31/538 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008 ,  A61K9/124 ,  A61K31/40 ,  A61K31/439 ,  A61K31/46 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition comprising:(a) a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; R2 is hydrogen, halogen, C1-4-alkyl, or O—C1-4-alkyl; and R3 is hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, or O—C1-4-alkylene-COO—C1-4-alkyl, or an enantiomer, mixture of enantiomers, or racemate thereof, or an acid addition salt with pharmacologically acceptable acids thereof, or a solvate or hydrate thereof; and (b) another active substance 2, wherein the molar ratio of the compound of formula 1 to the active substance 2 is 1:10 to 12:1.

    摘要翻译： 一种药物组合物，其包含：（a）式1的化合物，其中：n为1或2; R 1是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; R 2是氢，卤素，C 1-4 - 烷基或O-C 1-4 - 烷基; 和R 3是氢，C 1-4 - 烷基，OH，卤素，O-C 1-4 - 烷基，O-C 1-4 - 亚烷基-COOH或O-C 1-4亚烷基-COO-C 1-4 - 烷基， 或其对映异构体，对映体或其外消旋体的混合物，或其酸加成盐与其可药用酸或其溶剂合物或水合物; 和（b）另一种活性物质2，其中式1化合物与活性物质2的摩尔比为1:10至12:1。

    LONG ACTING BETA-2-AGONISTS AND THEIR USE AS MEDICAMENTS
    9.
    发明申请
    LONG ACTING BETA-2-AGONISTS AND THEIR USE AS MEDICAMENTS 有权

    公开(公告)号：US20080194550A1

    公开(公告)日：2008-08-14

    申请号：US12101462

    申请日：2008-04-11

    申请人： Thierry BOUYSSOU ,  Ingo KONETZKI ,  Philipp LUSTENBERGER ,  Juergen MACK ,  Andreas SCHNAPP ,  Dieter WIEDENMAYER ,  Christoph HOENKE ,  Klaus RUDOLF

    发明人： Thierry BOUYSSOU ,  Ingo KONETZKI ,  Philipp LUSTENBERGER ,  Juergen MACK ,  Andreas SCHNAPP ,  Dieter WIEDENMAYER ,  Christoph HOENKE ,  Klaus RUDOLF

    IPC分类号： A61K31/5415 ,  A61P11/00

    CPC分类号： C07D265/36 ,  C07D413/12

    摘要： A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.