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1.发明授权Crystalline form of the catalytic domain of Aurora 2 kinase and methods of use thereof 失效Aurora 2激酶催化结构域的结晶形式及其使用方法公开(公告)号：US07422885B1
公开(公告)日：2008-09-09
申请号：US10943438
申请日：2004-09-17
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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2.发明申请CRYSTALLINE FORM OF THE CATALYTIC DOMAIN OF AURORA 2 KINASE AND METHODS OF USE THEREOF 有权AURORA 2激酶的催化域的结晶形式及其使用方法公开(公告)号：US20090081706A1
公开(公告)日：2009-03-26
申请号：US12184770
申请日：2008-08-01
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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3.发明授权公开(公告)号：US07824491B2
公开(公告)日：2010-11-02
申请号：US12184770
申请日：2008-08-01
申请人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
发明人： Thierry O. Fischmann , Vincent S. Madison , Alan William Hruza , Paul Reichert , Lata Ramanathan , David Paul Sanden , Wolfgang Seghezzi
CPC分类号： C12N9/12
摘要： The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.
摘要翻译： 本发明公开了编码活性人Aurora 2激酶催化结构域的核酸。 本发明还公开了生长包含活性人Aurora 2激酶催化结构域的多肽的X射线衍射晶体的方法。 本发明还公开了人Aurora 2激酶的催化结构域的结晶形式。 此外，本发明公开了在结构辅助药物设计中使用人Aurora 2激酶的X射线衍射晶体的方法来鉴定可调节人Aurora 2激酶的酶活性的化合物。
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