公开(公告)号：US10946263B2

公开(公告)日：2021-03-16

申请号：US15683509

申请日：2017-08-22

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B24/00 ,  G09B19/00 ,  A63B71/06 ,  A63B22/00 ,  A63B21/00

Abstract: A system and method for optimizing a person's muscle group performance thru modulating the arm, leg, and core muscle exertion rate based upon the exerciser's metabolic and geographic data. The system uses real-time measurement gathering and storing of physiologic parameters from humans during physical exercise activity and the geographic data of the exercise activity to determine information for optimizing the exerciser's physical exercise performance of the basic working muscle groups in the rider's arms, legs, and core. The system broadcasts to exercisers information including, but are not limited to: a) the current condition of their monitored muscle tissue, b) which muscle groups the riders should modulate and change their level of energy output during the exercise activity, and c) level of energy exertion at which riders should be employing at that moment in the relevant working muscle groups to optimize their physical exercise performance.

公开(公告)号：US06486122B1

公开(公告)日：2002-11-26

申请号：US09559248

申请日：2000-04-26

Applicant: Daniel R. Twardzik ,  Stefan Paskell ,  Thomas S. Felker

Inventor： Daniel R. Twardzik ,  Stefan Paskell ,  Thomas S. Felker

IPC: A01N3718

CPC classification number: C07K14/495 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/465

Abstract: Disclosed are peptides related to human TGF-&agr;, having TGF-&agr; biological activity, which are useful for many of the indications that full-length TGF-&agr; polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-&agr; and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF-&agr; related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

Abstract translation: 公开了与具有TGF-α生物活性的人TGF-α相关的肽，其可用于许多适用于全长TGF-α多肽的适应症。 还提供了使用这些肽以及人TGF-α和生物相关多肽的方法。 例如，提供用于治疗或预防受试者的恶病质的方法以及用于刺激经历细胞毒性化疗的患者造血的方法。 此外，还提供了将TGF-α相关肽用于相关的神经再生疾病。 本发明的方法还为患有由胃肠道（GI）粘膜炎等副作用进行细胞毒性治疗的患者提供保护。

公开(公告)号：US11951375B2

公开(公告)日：2024-04-09

申请号：US17195034

申请日：2021-03-08

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B71/06 ,  A63B24/00 ,  A63B21/00 ,  A63B22/00 ,  G09B19/00

CPC classification number: A63B71/0622 ,  A63B24/00 ,  A63B24/0062 ,  A63B71/06 ,  A63B21/4041 ,  A63B22/0002 ,  A63B24/0087 ,  G09B19/00

Abstract: A system and method for optimizing a person's muscle group performance thru modulating the arm, leg, and core muscle exertion rate based upon the exerciser's metabolic and geographic data. The system uses real-time measurement gathering and storing of physiologic parameters from humans during physical exercise activity and the geographic data of the exercise activity to determine information for optimizing the exerciser's physical exercise performance of the basic working muscle groups in the rider's arms, legs, and core. The system broadcasts to exercisers information including, but are not limited to: a) the current condition of their monitored muscle tissue, b) which muscle groups the riders should modulate and change their level of energy output during the exercise activity, and c) level of energy exertion at which riders should be employing at that moment in the relevant working muscle groups to optimize their physical exercise performance.

公开(公告)号：US20210268360A1

公开(公告)日：2021-09-02

申请号：US17195034

申请日：2021-03-08

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B71/06 ,  A63B24/00

Abstract: A system and method for optimizing a person's muscle group performance thru modulating the arm, leg, and core muscle exertion rate based upon the exerciser's metabolic and geographic data. The system uses real-time measurement gathering and storing of physiologic parameters from humans during physical exercise activity and the geographic data of the exercise activity to determine information for optimizing the exerciser's physical exercise performance of the basic working muscle groups in the rider's arms, legs, and core. The system broadcasts to exercisers information including, but are not limited to: a) the current condition of their monitored muscle tissue, b) which muscle groups the riders should modulate and change their level of energy output during the exercise activity, and c) level of energy exertion at which riders should be employing at that moment in the relevant working muscle groups to optimize their physical exercise performance.

公开(公告)号：US20210268333A1

公开(公告)日：2021-09-02

申请号：US17222191

申请日：2021-04-05

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B23/035 ,  A63B22/00 ,  A63B23/02 ,  A63B22/06 ,  B62K21/12 ,  B62M3/14 ,  B62M15/00 ,  B62M1/12 ,  B62M23/00 ,  B62M1/26

Abstract: The function of this invention is to provide exercisers with a safe and easy way to convert a legs-only exercising device, such as a stationary trainer or bicycle, with the capacity to exercise their upper and lower body muscle groups simultaneously or separately. This invention is portable and can be moved easily from one legs-only exercising device to another. Once they are mounted onto the handlebar or attachment bar of the legs-only device, it is now a full-body trainer. Exercisers mount the trainer, place their feet on the cycling pedals, place their elbows onto the elbow holders, grasp the hand grips, and now start their full body exercising activity. The degree of difficulty of their exercise trek is easily accommodated by allowing the rider to adjust the resistance for moving the forearm bars up and down for an upright bike, or back and forth for a recumbent trainer.

公开(公告)号：US20180161658A1

公开(公告)日：2018-06-14

申请号：US15683509

申请日：2017-08-22

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B71/06 ,  A63B24/00

CPC classification number: A63B71/0622 ,  A63B21/4041 ,  A63B22/0002 ,  A63B24/00 ,  A63B24/0062 ,  A63B24/0087 ,  A63B71/06

Abstract: A system and method for optimizing a person's muscle group performance thru modulating the arm, leg, and core muscle exertion rate based upon the exerciser's metabolic and geographic data. The system uses real-time measurement gathering and storing of physiologic parameters from humans during physical exercise activity and the geographic data of the exercise activity to determine information for optimizing the exerciser's physical exercise performance of the basic working muscle groups in the rider's arms, legs, and core. The system broadcasts to exercisers information including, but are not limited to: a) the current condition of their monitored muscle tissue, b) which muscle groups the riders should modulate and change their level of energy output during the exercise activity, and c) level of energy exertion at which riders should be employing at that moment in the relevant working muscle groups to optimize their physical exercise performance.

公开(公告)号：US20150298761A1

公开(公告)日：2015-10-22

申请号：US14255790

申请日：2014-04-17

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: B62M1/12 ,  B62M3/14 ,  B62M3/08 ,  B62J99/00 ,  B62K23/06 ,  B62K23/08 ,  B62K3/16 ,  B62M1/36 ,  B62M9/00

CPC classification number: B62M1/12 ,  B62M2009/005

Abstract: The present invention relates to a rider's simultaneous use of his forearms/hands and legs to provide dual power into a propulsion system for riding a cycle vehicle, including a bicycle and a tricycle, or other vehicles. The invention permits the rider to have complete control turning the cycle vehicle, at will, right or left, while at the same time pumping a set of forearm/hand bars in an up power stroke and a down power stroke. In addition, even though the pumping action is lineally moving a telescoping rod and a push/pull cable back and forth, it is also simultaneously rotating a flywheel, upper and lower sprockets, and the crank axle to drive the bicycle wheel forward over the riding surface. Thus, the rider can provide maximum power into rotating the rear tire by simultaneously using both his arms and legs, while contemporaneously controlling his direction of travel.

Abstract translation: 本发明涉及骑手同时使用他的前臂/手和腿以将双重动力提供给用于骑行包括自行车和三轮车或其他车辆在内的循环车辆的推进系统。 本发明允许骑手具有完全的控制权，随意地向右或向左转动循环车辆，同时在上升动力冲程和下降动力冲程中泵送一组前臂/手杆。 另外，尽管泵送动作是线性地使伸缩杆和推拉电缆来回移动，但是它也同时旋转飞轮，上链轮和下链轮以及曲柄轴，从而将自行车车轮向前推过骑行 表面。 因此，骑手可以通过同时使用他的胳膊和腿部同时控制他的行进方向来提供最大的动力来旋转后轮胎。

公开(公告)号：US06764683B1

公开(公告)日：2004-07-20

申请号：US09459813

申请日：1999-12-13

Applicant: Daniel R. Twardzik ,  Stefan Paskell ,  Thomas S. Felker

Inventor： Daniel R. Twardzik ,  Stefan Paskell ,  Thomas S. Felker

IPC: A61K3819

CPC classification number: C07K14/495 ,  A61K38/00 ,  A61K48/00 ,  Y10S930/12

Abstract: There is disclosed a novel genus of small peptides, much smaller than human TGF&agr;, was discovered as having TGF&agr; biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGF&agr; polypeptide. There is further disclosed that TGF&agr; and consequently the genus of small peptides disclosed herein, was found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.

Abstract translation: 已经公开了一种新颖的小分子肽，比人TGFα小得多，被发现具有TGFα生物活性，因此可用作与全长TGFα多肽相同适应症的药理学试剂。 还公开了TGFα和因此本文公开的小肽属，发现具有刺激经历细胞毒性化疗的患者的造血作用的治疗活性，并且作为细胞保护剂用于保护患有经历癌细胞毒性治疗的患者从胃肠道（GI ）副作用，如粘膜炎，否则支持胃肠道的屏障功能，当它受到细胞毒性治疗的伤害时。

公开(公告)号：US06677307B2

公开(公告)日：2004-01-13

申请号：US10138158

申请日：2002-05-01

Applicant: Daniel R. Twardzik ,  Andre Pernet ,  Thomas S. Felker ,  Stefan Paskell ,  John M. Reno

Inventor： Daniel R. Twardzik ,  Andre Pernet ,  Thomas S. Felker ,  Stefan Paskell ,  John M. Reno

IPC: A61K3818

CPC classification number: C07K14/495 ,  A61K38/1841 ,  A61K48/00

Abstract: Disclosed are TGF-60 mimetics that PEGylated TGF-&agr; polypeptides and PEGylated TGF-60 related polypetides or fragments thereof.

Abstract translation: 公开了PEG-TGF-α多肽和PEG化的TGF-60相关多肽或其片段的TGF-60模拟物。

公开(公告)号：US11013955B2

公开(公告)日：2021-05-25

申请号：US16798903

申请日：2020-02-24

Applicant: Thomas S. Felker

Inventor： Thomas S. Felker

IPC: A63B23/035 ,  A63B22/00 ,  A63B23/02 ,  A63B22/06 ,  B62K21/12 ,  B62M3/14 ,  B62M15/00 ,  B62M1/12 ,  B62M23/00 ,  B62M1/26 ,  A63B21/04 ,  A63B21/22 ,  B62M3/00 ,  B62M9/00

Abstract: Tri-Power Exercising device allows a rider to simultaneously, or on demand, exercise virtually all muscle groups in his lower and upper body. The device includes a bicycle frame, pedals, forearm bars, sliding seat, computer and electronic display recommending energy modulation amounts from various muscle groups to optimize physical performance on any given trek. Because riders can exercise virtually all muscle groups at once, they reduce their exercising time, continuously builds muscle tissue throughout their whole body, and exercises their cardiovascular and respiratory systems completely. Riders operate the device by rotating legs on the pedals, rotationally oscillating the forearm bars up and down with their arms and shoulders, and then use core muscles to pull and push the seat back and forth on the slider. Inverted racks, pinion gears, and one-way bearings turn this linear power from the oscillating forearm bars and sliding seat into torque that rotates the crank axle.