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公开(公告)号：US20220017612A1
公开(公告)日：2022-01-20
申请号：US17465247
申请日：2021-09-02
发明人： Randall Burton , Jessie M. English , Barbara S. Fox , Stavros Kopsiaftis , Yacob Gomez Llorente , Renee Moore , Patricia Rao , Giovanna Scapin , Kenneth J. Simon , Haihong Zhou
IPC分类号： C07K16/18 , A61P35/04 , A61P35/00 , G01N33/574 , G01N33/68
摘要： Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
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公开(公告)号：US11130802B2
公开(公告)日：2021-09-28
申请号：US16597593
申请日：2019-10-09
发明人： Randall Burton , Jessie M. English , Barbara S. Fox , Stavros Kopsiaftis , Renee Moore , Patricia Rao , Kenneth J. Simon
摘要： Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
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