公开(公告)号：US08306752B1

公开(公告)日：2012-11-06

申请号：US12271944

申请日：2008-11-17

申请人： Timothy S. Gardner ,  James J. Collins ,  Boris Hayete ,  Jeremiah Faith

发明人： Timothy S. Gardner ,  James J. Collins ,  Boris Hayete ,  Jeremiah Faith

IPC分类号： G06F7/00

CPC分类号： G06F19/24 ,  G06F19/20

摘要： The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.

摘要翻译： 本发明涉及用于鉴定表达的调节多肽与这些调节多肽的调节活性的靶标之间的调节关系的计算机实现的方法和系统。 更具体地，本发明提供了用于鉴定细胞中生物化学物质之间的调节依赖性的新方法。 在特定实施方案中，提供了用于鉴定转录因子与转录因子的转录因子和基因靶标之间或转录因子与转录因子的一组基因靶标之间的调节相互作用的计算机实现的方法。 还提供了用于预测一组转录因子与其相应的一组转录靶标底物之间的调节相互作用的基因组大小的方法。