公开(公告)号：US20070203193A1

公开(公告)日：2007-08-30

申请号：US11743347

申请日：2007-05-02

申请人： Tiruvettipuram Thiruvengadam ,  Wenxue Wu ,  Tao Wang ,  John Chiu ,  Susan Bogdanowich-Knipp ,  Anastasia Palovsky ,  William Greenlee ,  Michael Graziano ,  Teddy Kosoglou ,  Madhu Chintala ,  Samuel Chackalamannil

发明人： Tiruvettipuram Thiruvengadam ,  Wenxue Wu ,  Tao Wang ,  John Chiu ,  Susan Bogdanowich-Knipp ,  Anastasia Palovsky ,  William Greenlee ,  Michael Graziano ,  Teddy Kosoglou ,  Madhu Chintala ,  Samuel Chackalamannil

IPC分类号： A61K31/443 ,  C07D405/06

CPC分类号： C07D417/14 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/06 ,  C07D405/14 ,  C07D413/14

摘要： A crystalline polymorph of a bislulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1, or which exhibits a differential scanning calorimtery profile substantially the same as that shown in FIG. 3, and is represented by the formula for Compound 2: and processes for preparing Compound 2 are disclosed. Pharmaceutical compositions comprising the polymorph of the bisulfate salt and at least one excipient or carrier, and methods of using the polymorph of Compound 2 to treat a variety of physiological disorders, such as thrombosis, are also disclosed.

摘要翻译： 凝血酶受体拮抗剂化合物的双硫酸盐的结晶多晶型物，其呈现与图1所示基本相同的粉末x射线衍射图。 1，或者显示与图1所示基本相同的差示扫描量热分析图。 3，由化合物2的式表示：公开了制备化合物2的方法。 还公开了包含硫酸氢盐和至少一种赋形剂或载体的多晶型物的药物组合物，以及使用化合物2的多晶型物来治疗各种生理学疾病如血栓形成的方法。