公开(公告)号：US20230381153A1

公开(公告)日：2023-11-30

申请号：US18196826

申请日：2023-05-12

申请人： Tisento Therapeutics Inc.

发明人： Joon Jung ,  Thomas Wai-Ho Lee ,  Rajesh R. Iyengar ,  Nicholas Robert Perl ,  Peter Germano ,  Maria D. Ribadeneira ,  Kim Tang

IPC分类号： A61K31/437 ,  A61P25/28 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519

CPC分类号： A61K31/437 ,  A61P25/28 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519

摘要： The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3′,5′-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.