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公开(公告)号:US20080317767A1
公开(公告)日:2008-12-25
申请号:US11547853
申请日:2005-04-08
申请人: Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Michael Munick , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
发明人: Tobias Braxmeier , Tim Friedrichson , Wolfgang Frohner , Gary Jennings , Michael Munick , Georg Schlechtingen , Cornelia Schroeder , Hans-Joachim Knolker , Kai Simons , Marino Zerial , Teymuras Kurzchalia
CPC分类号: A61K47/554 , A61K47/543
摘要: The present invention relates to a compound comprising a tripartite structure in the format C-B-A or C′-B′-A′ wherein moiety A and moiety A′ is a raftophile, moiety B and moiety B′ is a linker, moiety C and moiety C′ is a pharmacophore; and wherein moiety B and B′ is a linker which has a backbone of at least 8 carbon atoms and wherein one or more of said carbon atoms may be replaced by nitrogen, oxygen or sulfur. Furthermore, specific medical and pharmaceutical uses of the compounds of the invention are disclosed.
摘要翻译: 本发明涉及一种化合物,其包含CBA或C'-B'-A'形式的三方结构,其中部分A和部分A'为拉夫方,部分B和部分B'为连接体,部分C和部分C “是药效团; 并且其中部分B和B'是具有至少8个碳原子的主链的连接体,并且其中一个或多个所述碳原子可被氮,氧或硫代替。 此外,公开了本发明化合物的具体医药用途。