公开(公告)号：US20220143082A1

公开(公告)日：2022-05-12

申请号：US17580419

申请日：2022-01-20

申请人： Todd Alamin ,  Avram Allan Edidin ,  Hugues Malandain ,  Healey Montague-Alamin

发明人： Todd Alamin ,  Avram Allan Edidin ,  Hugues Malandain ,  Healey Montague-Alamin

IPC分类号： A61K35/13 ,  C12M1/00 ,  C12N5/09

摘要： Tumor tissue, including soft and/or bony tissue, are harvested from a subject and morcellated. The morcellated tissue is placed in a cartridge which is placed in a containment chamber of a tumor tissue processing device. Cancer cells in the morcellated tumor tissue are destroyed without destroying tumor antigens therein. These cells are destroyed cryogenically by exposing the cartridge to a cooling fluid such as liquid nitrogen, optionally with a warming cycle, and optionally with more than one freezing/thawing cycle. The treated tissue and/or cells are then extracted from the cartridge and reintroduced to the subject after they have reached a threshold condition. The treated tissue and/or cells can be reintroduced via a containment sleeve or a reimplantation bag.