公开(公告)号：US07449474B2

公开(公告)日：2008-11-11

申请号：US11111581

申请日：2005-04-21

申请人： Todd Andrew Brugel ,  Jennifer Anne Townes ,  Michael Philip Clark ,  Mark Sabat ,  Adam Golebiowski ,  Biswanath De ,  Stephen Matthew Berberich ,  Gregory Kent Bosch

发明人： Todd Andrew Brugel ,  Jennifer Anne Townes ,  Michael Philip Clark ,  Mark Sabat ,  Adam Golebiowski ,  Biswanath De ,  Stephen Matthew Berberich ,  Gregory Kent Bosch

IPC分类号： C07D239/48 ,  A61K31/506

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

公开(公告)号：US20090069342A1

公开(公告)日：2009-03-12

申请号：US12266212

申请日：2008-11-06

申请人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

发明人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

IPC分类号： C07D233/32 ,  A61K31/4166 ,  A61K31/4439 ,  C07D401/02 ,  C07D403/02 ,  A61K31/4178 ,  A61K31/497 ,  A61P9/00

CPC分类号： C07D233/38

摘要： The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

摘要翻译： 本发明涉及作为提供心房选择性抗心律失常药物的Kv1.5钾通道抑制剂有效的1-N-氨基-2-咪唑啉酮及其衍生物。 本发明还涉及包含所述Kv1.5钾通道抑制剂的组合物，以及用于治疗心律失常的方法。

公开(公告)号：US07803827B2

公开(公告)日：2010-09-28

申请号：US12266212

申请日：2008-11-06

申请人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

发明人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

IPC分类号： A61K31/4166 ,  C07D233/32

CPC分类号： C07D233/38

摘要： The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

摘要翻译： 本发明涉及作为提供心房选择性抗心律失常药物的Kv1.5钾通道抑制剂有效的1-N-氨基-2-咪唑啉酮及其衍生物。 本发明还涉及包含所述Kv1.5钾通道抑制剂的组合物，以及用于治疗心律失常的方法。

公开(公告)号：US07504517B2

公开(公告)日：2009-03-17

申请号：US11765359

申请日：2007-06-19

申请人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

发明人： John Michael Janusz ,  Stephen Joseph Hodson ,  Gregory Kent Bosch ,  Ronald Eugene White ,  Benjamin E. Blass ,  Christopher M. Jackson ,  Neil T. Fairweather

IPC分类号： C07D233/38 ,  A61K31/4166

CPC分类号： C07D233/38

摘要： The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.

摘要翻译： 本发明涉及作为提供心房选择性抗心律失常药物的Kv1.5钾通道抑制剂有效的1-N-氨基-2-咪唑啉酮及其衍生物。 本发明还涉及包含所述Kv1.5钾通道抑制剂的组合物，以及用于治疗心律失常的方法。

公开(公告)号：US07304084B2

公开(公告)日：2007-12-04

申请号：US11332998

申请日：2006-01-17

申请人： Jared Lynn Randall ,  Richard Alan Gibbs ,  Gregory Kent Bosch ,  Michael David Curtis ,  Li Sun ,  Nicholas Nikolaides

发明人： Jared Lynn Randall ,  Richard Alan Gibbs ,  Gregory Kent Bosch ,  Michael David Curtis ,  Li Sun ,  Nicholas Nikolaides

IPC分类号： A61K31/4181

CPC分类号： C07D235/06

摘要： 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

摘要翻译： 6 - [（4,5-二氢-1H-咪唑-2-基）氨基] -7-甲基-1H-苯并咪唑-4-甲腈基本上不含2,3,7-三氨基-4,6-二甲基 - 1,9-吩嗪腈和其无水单乙酸盐可用于治疗α-2介导的病症如高眼压症。