公开(公告)号：US11052154B2

公开(公告)日：2021-07-06

申请号：US16349689

申请日：2017-11-13

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko Miyamoto ,  Masaaki Ozawa

IPC: A61K47/54 ,  A61P35/00 ,  A61K38/05

Abstract: A Ras protein degradation inducing molecule that can induce degradation of Ras proteins, and a pharmaceutical composition that contains this Ras protein degradation inducing molecule are provided. The Ras protein degradation inducing molecule is a conjugate of a Ras protein affinity molecule which has affinity to Ras proteins, and a proteolysis-inducing tag which has affinity to protease and does not inhibit proteolysis of proteins by the protease.

公开(公告)号：US11007269B2

公开(公告)日：2021-05-18

申请号：US16349708

申请日：2017-11-13

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko Miyamoto ,  Masaaki Ozawa

IPC: A61K47/54 ,  A61P7/04 ,  A61P35/00 ,  A61K31/167

Abstract: A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.

公开(公告)号：US10976306B2

公开(公告)日：2021-04-13

申请号：US15736089

申请日：2016-06-15

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko Miyamoto ,  Masaaki Ozawa

IPC: G01N33/50 ,  C07D239/49 ,  C07K5/00 ,  C12Q1/02 ,  A61K38/00 ,  C12N9/00 ,  C07K14/47 ,  C12N9/76 ,  C12P21/06

Abstract: Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.