公开(公告)号：US20200261552A1

公开(公告)日：2020-08-20

申请号：US16611883

申请日：2018-05-14

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro IWAKURA ,  Tomonori KAIFU

IPC: A61K38/47 ,  A61P37/06 ,  A61P19/02

Abstract: Provided are: a pharmaceutical composition for curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor, in which the pharmaceutical composition contains a carbohydrate modifying enzyme as an active ingredient; and a method of curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor.

公开(公告)号：US20230295280A1

公开(公告)日：2023-09-21

申请号：US17267672

申请日：2019-10-11

Applicant: Tokyo University of Science Foundation

Inventor： Yoichiro IWAKURA ,  Rikio YABE

IPC: C07K16/18 ,  C07K14/78 ,  A61P19/02 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61P19/02 ,  C07K14/78 ,  G01N33/68 ,  G01N2333/78

Abstract: Provided are: a maturation suppressor for dendritic cells, said maturation suppressor inhibiting the binding of TARM1 protein to collagen protein to thereby suppress the maturation of dendritic cells; a maturation suppression method for dendritic cells, said method comprising using the maturation suppressor; a pharmaceutical composition containing the maturation suppressor as an active ingredient; a method for screening a maturation suppressor for dendritic cells; and a method for screening a therapeutic component for a disease mediated by dendritic cells.

公开(公告)号：US20210040218A1

公开(公告)日：2021-02-11

申请号：US16991528

申请日：2020-08-12

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro IWAKURA ,  Noriyuki Fujikado ,  Guangyu Ma

IPC: C07K16/28 ,  A61K31/737 ,  G01N33/50

Abstract: An object of the present invention is to find a ligand for a DCIR and to search for an agonist and an antagonist for the DCIR.
Specifically, disclosed are: a dendritic cell immunoreceptor agonist containing keratan sulfate-II (KS-II) as an active ingredient; an antibody against dendritic cell immunoreceptor, having a keratan sulfate-II-like dendritic cell immunoreceptor agonism; and an antibody against a dendritic cell immunoreceptor, having a keratan sulfate-II inhibitory dendritic cell immunoreceptor antagonism.