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    Plasminogen fragment having activity to inhibit tumor metastasis and growth and process for preparing same technical field
    3.
    发明申请
    Plasminogen fragment having activity to inhibit tumor metastasis and growth and process for preparing same technical field 审中-公开

    公开(公告)号：US20060147441A1

    公开(公告)日：2006-07-06

    申请号：US11378647

    申请日：2006-03-20

    申请人： Wataru Morikawa ,  Seiji Miyamoto

    发明人： Wataru Morikawa ,  Seiji Miyamoto

    IPC分类号： A61K38/46

    CPC分类号： A61K38/484

    摘要： The present invention provides a plasminogen fragment with the activity to inhibit tumor metastasis and growth, a process for preparing said fragment and an agent for inhibiting tumor metastasis and growth comprising said fragment as an active ingredient. The plasminogen fragment of the present invention is prepared from a elastase lysate of Lys-Plasminogen, which is produced by treating a natural plasminogen with plasmin, and preferably exhibits a strong heparin binding activity. The agent for inhibiting tumor metastasis and growth comprising the plasminogen fragment as an active ingredient of the present invention is useful for clinically treating solid cancers such as lung cancer or colon cancer.

    Enzyme producing plasma protein fragment having inhibitory activity to metastasis and growth of cancer and plasma protein fragment produced by fragmentation by said enzyme
    4.
    发明申请
    Enzyme producing plasma protein fragment having inhibitory activity to metastasis and growth of cancer and plasma protein fragment produced by fragmentation by said enzyme 审中-公开
    产生产生血浆蛋白质的蛋白质片段，其具有通过所述酶片段产生的癌转移和生长抑制活性和血浆蛋白质片段

    公开(公告)号：US20070117180A1

    公开(公告)日：2007-05-24

    申请号：US11542180

    申请日：2006-10-04

    申请人： Wataru Morikawa ,  Kazuyoshi Kaminaka ,  Sumiyo Takemoto ,  Hiroaki Maeda ,  Chikateru Nozaki ,  Seiji Miyamoto

    发明人： Wataru Morikawa ,  Kazuyoshi Kaminaka ,  Sumiyo Takemoto ,  Hiroaki Maeda ,  Chikateru Nozaki ,  Seiji Miyamoto

    IPC分类号： C12P21/06

    CPC分类号： C12N9/6454 ,  A61K35/00 ,  C12N9/6435 ,  C12N9/6478 ,  C12Y304/21007

    摘要： An aspartic enzyme having a high homology with a cathepsin D precursor, which is a protein having the N-terminal amino acid sequence LVRIPLHKFT (SEQ ID NO: 1) and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins, typically plasminogen, to produce plasma protein fragments having an inhibitory activity to metastasis and growth of cancer; the plasma protein fragments having an inhibitory activity to metastasis and growth of cancer which is prepared via the degradation with the above enzyme; a process for preparing the protein fragments which comprises degrading plasma proteins with the above enzyme; and a medicament for treating and preventing metastasis and growth of cancer which comprises as a major ingredient the above enzyme or the plasma protein fragments.

    摘要翻译： 与组织蛋白酶D前体具有高同源性的天冬氨酸酶，其是具有N-末端氨基酸序列LVRIPLHKFT（SEQ ID NO：1）并且在非还原性SDS电泳中显示约45kDa的分子量的蛋白质，并且可以 降解血浆蛋白质，通常是纤溶酶原，产生具有对癌症转移和生长具有抑制活性的血浆蛋白片段; 血浆蛋白片段通过用上述酶的降解制备具有对癌症转移和生长的抑制活性; 一种制备蛋白片段的方法，包括用上述酶降解血浆蛋白; 以及用于治疗和预防癌症转移和生长的药物，其包含作为上述酶或血浆蛋白片段的主要成分。