公开(公告)号：US5116828A

公开(公告)日：1992-05-26

申请号：US603214

申请日：1990-10-25

申请人： Tomoshi Miura ,  Shinichiro Aonuma ,  Hiroyuki Ohara

发明人： Tomoshi Miura ,  Shinichiro Aonuma ,  Hiroyuki Ohara

IPC分类号： A61K31/195 ,  A61K31/565 ,  A61K38/24 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00

CPC分类号： A61K31/565 ,  A61K38/24

摘要： A pharmaceutical composition for the treatment of osteoporosis comprises an estrogen and a thyroid hormone as effective ingredients. By using the estrogen in combination with the thyroid hormone, a more excellent activity of increasing bone amount can be obtained than in the case of administering the estrogen alone.

公开(公告)号：US08236844B2

公开(公告)日：2012-08-07

申请号：US12087591

申请日：2007-01-23

申请人： Ko Nakamura ,  Yoshitaka Nakazawa ,  Minoru Kawamura ,  Kunihiko Higashiura ,  Tomoshi Miura

发明人： Ko Nakamura ,  Yoshitaka Nakazawa ,  Minoru Kawamura ,  Kunihiko Higashiura ,  Tomoshi Miura

IPC分类号： C07D233/64 ,  A61K31/4172

CPC分类号： C07D233/64 ,  A61K31/4172

摘要： A novel histidine derivative represented by the following formula (I), and a pharmaceutically acceptable salt and hydrate thereof, useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases: wherein, R1 is hydrogen, alkyl having 1 to 6 carbon(s) or benzyl which may be substituted with alkyl having 1 to 4 carbon(s) or halogen; R2 is hydrogen or alkyl having 1 to 4 carbon(s); R3 and R4 are same or different and each is hydrogen, alkyl having 1 to 4 carbon(s) or phenyl which may be substituted with any one or two of alkyl having 1 to 6 carbon(s), alkoxy having 1 to 6 carbon(s), halogen, trifluoromethyl, nitro and cyano; and R5 is hydrogen or an alkyl group having 1 to 4 carbon(s).

摘要翻译： 由下式（I）表示的新型组氨酸衍生物及其药学上可接受的盐和水合物，可用作治疗各种急性或慢性疼痛疾病和神经性疼痛疾病的止​​痛药等药剂，其中， R1是氢，具有1至6个碳原子的烷基或可被具有1至4个碳原子的烷基或卤素取代的苄基; R2是氢或具有1至4个碳的烷基; R3和R4相同或不同，各自为氢，可具有1至4个碳的烷基或可被具有1至6个碳的烷基的任何一个或两个的烷基取代的苯基，具有1至6个碳的烷氧基（ s），卤素，三氟甲基，硝基和氰基; 并且R 5是氢或具有1至4个碳的烷基。

公开(公告)号：US20090149658A1

公开(公告)日：2009-06-11

申请号：US12087591

申请日：2007-01-23

申请人： Ko Nakamura ,  Yoshitaka Nakazawa ,  Minoru Kawamura ,  Kunihiko Higashiura ,  Tomoshi Miura

发明人： Ko Nakamura ,  Yoshitaka Nakazawa ,  Minoru Kawamura ,  Kunihiko Higashiura ,  Tomoshi Miura

IPC分类号： C07D233/64

CPC分类号： C07D233/64 ,  A61K31/4172

摘要： The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention is very useful as a pharmaceutical agent such as analgesics for the treatment of various kinds of acute or chronic pain diseases and of neuropathic pain diseases.

摘要翻译： 本发明提供一种作为优异止痛剂有用的新型化合物。 本发明提供具有优异止痛作用的新型组氨酸衍生物等。 本发明的化合物作为治疗各种急性或慢性疼痛疾病和神经性疼痛疾病的止​​痛剂等药剂是非常有用的。