公开(公告)号：US20070298039A1

公开(公告)日：2007-12-27

申请号：US11760491

申请日：2007-06-08

申请人： Tong Zhou ,  Kimihisa Ichikawa ,  Robert Kimberly ,  William Koopman

发明人： Tong Zhou ,  Kimihisa Ichikawa ,  Robert Kimberly ,  William Koopman

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/30 ,  C12N15/63 ,  C12N5/02 ,  C12N5/10

CPC分类号： A61K39/39558 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/6863

摘要： An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of o the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

摘要翻译： 本发明的抗体与人DR5相互作用以在受体的下游产生激动或拮抗作用，包括抑制细胞增殖和细胞凋亡。 已经阐明了抗DR5抗体的核酸序列和氨基酸序列，并且已经产生含有和表达这些序列的载体和细胞。 具体涉及抗体的方法和用途，包括治疗凋亡相关疾病和治疗失调的细胞生长。