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公开(公告)号：US10918844B2
公开(公告)日：2021-02-16
申请号：US14707496
申请日：2015-05-08
发明人： Daizo Uemura
摘要： A needle-like structure includes projections formed in rows on a substrate and extended in a direction, and needle portions formed on each of the projections such that the needle portions are spaced part from one another.
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公开(公告)号：US10799691B2
公开(公告)日：2020-10-13
申请号：US15586447
申请日：2017-05-04
发明人： Daizo Uemura , Kazuhiko Shiomitsu
摘要： A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.
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公开(公告)号：US10471245B2
公开(公告)日：2019-11-12
申请号：US15355264
申请日：2016-11-18
发明人： Daizo Uemura
摘要： A method of manufacturing a needle-shaped body includes forming a needle-shaped body precursor such that the needle-shaped body precursor has a base portion and a needle-shaped portion on the base portion, and that the needle-shaped portion has a portion which contacts the base portion and has a form of a polygon, producing a needle-shaped body original plate by forming a curved surface portion in at least a portion of an apex portion of the polygon in a junction portion at a boundary between the base portion and the needle-shaped portion, producing a resin plate by transfer molding with the needle-shaped body original plate such that the resin plate has a concave pattern corresponding to the needle-shaped portion and the curved surface portion, and producing a needle-shaped body by transfer molding with the resin plate such that the needle-shaped body has a transferred needle-shaped portion and a transferred curved surface portion.
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公开(公告)号：US20170232246A1
公开(公告)日：2017-08-17
申请号：US15586447
申请日：2017-05-04
发明人： Daizo Uemura , Kazuhiko Shiomitsu
IPC分类号： A61M37/00
摘要： A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.
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