公开(公告)号：US20110152178A1

公开(公告)日：2011-06-23

申请号：US13061370

申请日：2009-08-07

申请人： Toshinori Sato ,  Goshi Ishihara

发明人： Toshinori Sato ,  Goshi Ishihara

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61P31/16

CPC分类号： C07K7/08 ,  A61K38/00

摘要： The present invention provides a self-assembly of a compound or of a pharmaceutically acceptable salt thereof, the compound being represented by formula (I) R1-Gly Leu Ala Met Ala Pro Ser Val Gly His Val Arg Gln His Gly-R2  (I) (wherein R1 represents a linear or branched acyl group having 14 to 24 carbon atoms; R2 represents OH, NH2, NR3R4, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryloxy group, or a substituted or unsubstituted aralkyloxy group; and R3 and R4 independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, an alkoxy group, or a hydroxy group, provided that both R3 and R4 do not represent a hydroxy group or an alkoxy group simultaneously).

摘要翻译： 本发明提供化合物或其药学上可接受的盐的自组装，所述化合物由式（I）表示：R1-Gly Leu Ala Met Ala Pro Ser Val Gly His Val Arg Gln His Gly-R2（I） （其中R1表示具有14-24个碳原子的直链或支链酰基; R2表示OH，NH2，NR3R4，取代或未取代的烷氧基，取代或未取代的芳氧基或取代或未取代的芳烷氧基; R3和 R4独立地表示取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳烷基，烷氧基或羟基，条件是R 3和R 4同时不表示羟基或烷氧基 ）。