公开(公告)号：US11253605B2

公开(公告)日：2022-02-22

申请号：US15907131

申请日：2018-02-27

申请人： Translate Bio, Inc.

发明人： Anusha Dias ,  Jonathan Abysalh ,  Brian Bettencourt ,  Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K47/69 ,  A61K47/64 ,  A61K9/127 ,  C12N15/10 ,  A61K38/17 ,  C07K14/47 ,  A61P11/00 ,  A61K9/00 ,  A61K31/7105

摘要： The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.

公开(公告)号：US20220193247A1

公开(公告)日：2022-06-23

申请号：US17570352

申请日：2022-01-06

申请人： Translate Bio, Inc.

发明人： Anusha Dias ,  Jonathan Abysalh ,  Brian Bettencourt ,  Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K47/64 ,  A61K9/127 ,  C12N15/10 ,  A61K38/17 ,  C07K14/47 ,  A61K47/69 ,  A61P11/00 ,  A61K9/00 ,  A61K31/7105

摘要： The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.

公开(公告)号：US20180256741A1

公开(公告)日：2018-09-13

申请号：US15907131

申请日：2018-02-27

申请人： Translate Bio, Inc.

发明人： Anusha Dias ,  Jonathan Abysalh ,  Brian Bettencourt ,  Frank DeRosa ,  Michael Heartlein

IPC分类号： A61K47/64 ,  A61P11/00 ,  A61K31/7105 ,  A61K47/69 ,  A61K9/127 ,  A61K9/00

摘要： The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.