公开(公告)号：US20250057765A1

公开(公告)日：2025-02-20

申请号：US18782767

申请日：2024-07-24

Applicant: Translate Bio, Inc.

Inventor： Christian Cobaugh ,  Richard Wooster ,  Frank DeRosa ,  Anusha Dias ,  Shrirang Karve

IPC: A61K9/127 ,  A61K9/00 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides, among other things, methods and compositions for cancer treatment. The methods and compositions disclosed herein are particularly effective in reducing the size/volume of a tumor and inhibiting tumor growth.

公开(公告)号：US20210145860A1

公开(公告)日：2021-05-20

申请号：US17076195

申请日：2020-10-21

Applicant: Translate Bio, Inc.

Inventor： Richard Wooster ,  Anusha Dias ,  Dustin Cooper ,  Christian Cobaugh ,  Frank DeRosa ,  Tim Efthymiou ,  Jeffrey S. Dubins

IPC: A61K31/7105 ,  A61K47/54 ,  A61K47/60 ,  A61K47/69

Abstract: The present invention provides, among other things, methods and compositions for selective degradation of proteins. In some aspects, messenger RNAs (mRNAs) are described that encode a ubiquitin pathway moiety and a binding peptide that binds a target protein, wherein the mRNA is encapsulated within a lipid nanoparticle. Also provided herein are mRNAs that encode at least two binding peptides, wherein a first binding peptide binds a ubiquitin pathway moiety and a second binding peptide binds a target protein, and wherein the mRNA is encapsulated within a lipid nanoparticle.

公开(公告)号：US12076438B2

公开(公告)日：2024-09-03

申请号：US17066919

申请日：2020-10-09

Applicant: Translate Bio, Inc.

Inventor： Christian Cobaugh ,  Richard Wooster ,  Frank DeRosa ,  Anusha Dias ,  Shrirang Karve

IPC: A61K9/127 ,  A61K9/00 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/007 ,  A61K9/0078 ,  A61K38/1709 ,  A61K38/19 ,  A61K38/193 ,  A61K38/208 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides, among other things, methods and compositions for cancer treatment. The methods and compositions disclosed herein are particularly effective in reducing the size/volume of a tumor and inhibiting tumor growth.

公开(公告)号：US20210106527A1

公开(公告)日：2021-04-15

申请号：US17066919

申请日：2020-10-09

Applicant: Translate Bio, Inc.

Inventor： Christian Cobaugh ,  Richard Wooster ,  Frank DeRosa ,  Anusha Dias ,  Shrirang Karve

IPC: A61K9/127 ,  A61K38/20 ,  A61K38/17 ,  A61K38/19 ,  A61P35/00 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention provides, among other things, methods and compositions for cancer treatment. The methods and compositions disclosed herein are particularly effective in reducing the size/volume of a tumor and inhibiting tumor growth.

公开(公告)号：US20240197825A1

公开(公告)日：2024-06-20

申请号：US17761893

申请日：2020-09-17

Applicant: Translate Bio, Inc.

Inventor： Richard Wooster ,  Frank DeRosa ,  Lianne Boeglin ,  Priyaanka Nanduri ,  Anusha Dias ,  Khang Anh Tran

IPC: A61K38/17 ,  A61K48/00

CPC classification number: A61K38/177 ,  A61K48/0033 ,  A61K48/005

Abstract: The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding an engineered or mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.