公开(公告)号：US20210187122A1

公开(公告)日：2021-06-24

申请号：US17016860

申请日：2020-09-10

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Jonathan Cherry ,  Paula Lewis ,  Shrirang Karve ,  Zarna Patel ,  Darshan Parekh ,  Susan Wood ,  Chi-Sung Chiu ,  Caroline J. Woo

IPC: A61K48/00 ,  C12N15/62 ,  A61K38/02 ,  A61K9/127 ,  A61K38/17 ,  A61P21/00 ,  C12N15/52 ,  A61K9/00 ,  A61P43/00 ,  C12N15/88 ,  A61K31/7088 ,  A61K9/107

Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.

公开(公告)号：US20180369413A1

公开(公告)日：2018-12-27

申请号：US16012138

申请日：2018-06-19

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Jonathan Cherry ,  Paula Lewis ,  Shrirang Karve ,  Zarna Patel ,  Darshan Parekh ,  Susan Wood ,  Chi-Sung Chiu ,  Caroline J. Woo

IPC: A61K48/00 ,  C12N15/62 ,  A61K38/02 ,  C12N15/52 ,  A61K38/17 ,  A61P21/00 ,  A61K9/127

Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.

公开(公告)号：US10780183B2

公开(公告)日：2020-09-22

申请号：US16012138

申请日：2018-06-19

Applicant: Translate Bio, Inc.

Inventor： Michael Heartlein ,  Frank DeRosa ,  Jonathan Cherry ,  Paula Lewis ,  Shrirang Karve ,  Zarna Patel ,  Darshan Parekh ,  Susan Wood ,  Chi-Sung Chiu ,  Caroline J. Woo

IPC: A61P21/00 ,  A61K48/00 ,  A61K38/17 ,  A61K9/127 ,  C12N15/62 ,  A61K38/02 ,  C12N15/52 ,  A61K9/00 ,  A61P43/00 ,  C12N15/88 ,  A61K31/7088 ,  A61K9/107

Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.