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公开(公告)号：US20030097123A1
公开(公告)日：2003-05-22
申请号：US10098909
申请日：2002-03-13
IPC分类号： A61B018/18
CPC分类号： A61B18/20 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/15138 , A61B5/411 , A61B17/3476 , A61B18/203 , A61B2010/008 , A61B2017/00057 , A61B2017/00765 , A61B2018/00452 , A61B2090/395 , A61B2218/008 , A61M37/00 , A61M2037/0007 , H04R25/75
摘要： The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the still before or after laser irradiation.
摘要翻译： 本发明提供了一种通过患者的皮肤除去流体，气体或其它生物分子或递送药物组合物而不使用尖锐或针状物的改进方法。 该方法包括使用激光照射角质层，施用的药物或吸收材料的步骤。 通过选择参数，激光照射所选择的材料或组织以产生压力梯度，血浆，气穴气泡或其他形式的组织消融或改变。 这些方法增加了药物向身体外的气体或其他生物分子的扩散。 对于本发明，药物组合物可以应用于激光照射之前或之后。
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公开(公告)号：US20040127815A1
公开(公告)日：2004-07-01
申请号：US10734529
申请日：2003-12-11
IPC分类号： A61B010/00 , A61B018/18
CPC分类号： A61B18/20 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/15138 , A61B5/411 , A61B17/3476 , A61B18/203 , A61B2010/008 , A61B2017/00057 , A61B2017/00765 , A61B2018/00452 , A61B2090/395 , A61B2218/008 , A61M37/00 , A61M2037/0007 , H04R25/75
摘要： The present invention provides an improved method of measuring analytes in body fluids without the use of a sharp. The method having the steps of irradiating the skin of a patient by focused pulses of electromagnetic energy emitted by a laser. By proper selection of wavelength, energy fluence, pulse temporal width and irradiation spot size, the pulses precisely irradiate the skin to a selectable depth, without causing clinically relevant damage to healthy portions of the skin. After irradiation, interstitial fluid is collected into a container or left on the skin. The interstitial fluid is then tested for a desired analyte to approximate the analyte concentration in other body fluids. Alternatively, after the forced formation of a microblister, the epidermis covering the microblister is lysed and the interstitial fluid is subsequently collected and tested.
摘要翻译： 本发明提供了一种在不使用尖锐的情况下测量体液中分析物的改进方法。 该方法具有通过激光发射的电磁能量的聚焦脉冲照射患者的皮肤的步骤。 通过适当选择波长，能量注量，脉冲时间宽度和照射点尺寸，脉冲将皮肤精确地照射到可选择的深度，而不会对皮肤的健康部分造成临床相关的损害。 照射后，将间质液收集到容器中或留在皮肤上。 然后将组织液测试所需的分析物以接近其他体液中的分析物浓度。 或者，在强制形成微型细胞之后，将覆盖微泡的表皮裂解，随后收集和测试间质液。
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公开(公告)号：US20030045867A1
公开(公告)日：2003-03-06
申请号：US10091957
申请日：2002-03-05
IPC分类号： A61B018/18 , A61N001/30
CPC分类号： A61B18/20 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/15138 , A61B5/411 , A61B17/3476 , A61B18/203 , A61B2010/008 , A61B2017/00057 , A61B2017/00765 , A61B2018/00452 , A61B2090/395 , A61B2218/008 , A61M37/00 , A61M2037/0007 , H04R25/75
摘要： The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the skin before or after laser irradiation.
摘要翻译： 本发明提供了一种通过患者的皮肤除去流体，气体或其它生物分子或递送药物组合物而不使用尖锐或针状物的改进方法。 该方法包括使用激光照射角质层，施用的药物或吸收材料的步骤。 通过选择参数，激光照射所选择的材料或组织以产生压力梯度，血浆，气穴气泡或其他形式的组织消融或改变。 这些方法增加了药物向身体外的气体或其他生物分子的扩散。 对于本发明，药物组合物可以在激光照射之前或之后施用于皮肤。
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公开(公告)号：US20020133147A1
公开(公告)日：2002-09-19
申请号：US10083088
申请日：2002-02-26
IPC分类号： A61B018/18
CPC分类号： A61B18/20 , A61B5/150022 , A61B5/150076 , A61B5/150099 , A61B5/15138 , A61B5/411 , A61B17/3476 , A61B18/203 , A61B2010/008 , A61B2017/00057 , A61B2017/00765 , A61B2018/00452 , A61B2090/395 , A61B2218/008 , A61M37/00 , A61M2037/0007 , H04R25/75
摘要： The present invention provides an improved method of measuring analytes in bodily fluids without the use of a sharp. The method having the steps of irradiating the skin of a patient by focused pulses of electromagnetic energy emitted by a laser. By proper selection of wavelength, energy fluence, pulse temporal width and irradiation spot size, the pulses precisely irradiate the skin to a selectable depth, without causing clinically relevant damage to healthy portions of the skin. After irradiation, interstitial fluid is collected into a container or left on the skin. The interstitial fluid is then tested for a desired analyte to approximate the analyte concentration in other bodily fluids. Alternatively, after the forced formation of a microblister, the epidermis covering the microblister is lysed and the interstitial fluid is subsequently collected and tested.
摘要翻译： 本发明提供了一种在不使用尖锐的情况下测量体液中分析物的改进方法。 该方法具有通过激光发射的电磁能量的聚焦脉冲照射患者的皮肤的步骤。 通过适当选择波长，能量注量，脉冲时间宽度和照射点尺寸，脉冲将皮肤精确地照射到可选择的深度，而不会对皮肤的健康部分造成临床相关的损害。 照射后，将间质液收集到容器中或留在皮肤上。 然后测试间质液体以获得所需的分析物以接近其他体液中的分析物浓度。 或者，在强制形成微型细胞之后，将覆盖微泡的表皮裂解，随后收集和测试间质液。
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