公开(公告)号：US20240076248A1

公开(公告)日：2024-03-07

申请号：US18261493

申请日：2022-01-24

申请人： Trasis S.A.

发明人： Thomas VERGOTE ,  Julien MASSET ,  Corentin WARNIER ,  Jean-Luc MORELLE ,  Charles VRIAMONT ,  Frederique BLANC-BEGUIN ,  Pierre-Yves LEROUX ,  Peter EU

IPC分类号： C07B59/00 ,  A61K51/08 ,  A61K51/12 ,  C07K1/34

CPC分类号： C07B59/008 ,  A61K51/081 ,  A61K51/1255 ,  C07K1/34 ,  C07B2200/05

摘要： A method for synthesis and purification of radiolabeled macroaggregated human serum albumin (MAA) to form a bulk solution injectable to a patient includes: providing a radiometal in a generator, the radiometal being a generator eluate; synthesizing the radiolabeled MAA in a reactor with MAA particles from a commercially available labeling kit for 99mTc and the generator eluate so as to provide synthesized radiolabeled MAA particles; passing the synthesized radiolabeled MAA particles on a syringe filter membrane having a membrane composition, diameter, and pore size for trapping the radiolabeled MAA particles as trapped radiolabeled MAA particles and not retaining impurities from a bulk solution, the impurities including free radioactive metal isotopes, parent radioactive metal breakthrough, and stannous chloride present in the MAA labeling kit for 99mTc; and untrapping the trapped radiolabeled MAA particles from the syringe filter using a saline or buffered solution passing through the syringe filter.