公开(公告)号：US09688744B2

公开(公告)日：2017-06-27

申请号：US14697459

申请日：2015-04-27

申请人： Trellis Bioscience, LLC

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC分类号： A61K39/395 ,  C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

CPC分类号： C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

公开(公告)号：US10030069B2

公开(公告)日：2018-07-24

申请号：US15464165

申请日：2017-03-20

申请人： Trellis Bioscience, LLC ,  Laurie M. Usinger

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC分类号： C07K16/08 ,  C07K16/46 ,  A61K39/245 ,  A61K39/00

摘要： Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.